Tryptanthrin Protects Hepatocytes against Oxidative Stress <i>via</i> Activation of the Extracellular Signal-Regulated Kinase/NF-E2-Related Factor 2 Pathway
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چکیده
منابع مشابه
Tryptanthrin protects hepatocytes against oxidative stress via activation of the extracellular signal-regulated kinase/NF-E2-related factor 2 pathway.
Tryptanthrin [6,12-dihydro-6,12-dioxoindolo-(2,1-b)-quinazoline], originally isolated from Isatidis radix, has been characterized as having anti-microbial and anti-tumor activities. It is well-known that excess oxidative stress is one of the major factors causing cell damage in the liver. This study investigated the cytoprotective effects and molecular mechanism of tryptanthrin against tert-but...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2014
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b14-00363